MORPHOLOGICAL CHARACTERISTICS OF TYROCYTES IN RATS UNDER LONG EXPOSURE OF TETRAHLOROMETHANE IN EXPERIMENT
Keywords:
thyrocyte, thyroid gland, chronic intoxication, adaptationAbstract
The article describes the main pathomorphological changes in thyrocytes at different periods of the experiment when using hepatotoxic poison (carbon tetrachloride) in order to simulate chronic liver failure. The thyroid parenchyma was assessed after the cessation of toxic effects on days 7, 30, 60 days and 90 days in order to determine the adaptive capabilities of thyrocytes. It was found that with an increase in the concentration of endogenous toxic compounds in the blood of animals, damage is characterized by small-droplet vacuolar degeneration, as well as tissue dystrophy, followed by the formation of zones of moderate proliferation and isolation of follicles into separate thyreones due to connective tissue. This fact indicates morphological restructuring of the parenchyma with possible zones of nodulation, which can serve as a morphological substrate for thyropathies.
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