MORPHOLOGICAL CHARACTERISTICS OF TYROCYTES IN RATS UNDER LONG EXPOSURE OF TETRAHLOROMETHANE IN EXPERIMENT

Authors

  • S. Kalashnikova Volgograd Medical State University of the Ministry of Health care of Russia
  • L. Polyakova Volgograd Medical State University of the Ministry of Health care of Russia
  • E. Kalashnikova Volgograd Medical State University of the Ministry of Health care of Russia

Keywords:

thyrocyte, thyroid gland, chronic intoxication, adaptation

Abstract

The article describes the main pathomorphological changes in thyrocytes at different periods of the experiment when using hepatotoxic poison (carbon tetrachloride) in order to simulate chronic liver failure. The thyroid parenchyma was assessed after the cessation of toxic effects on days 7, 30, 60 days and 90 days in order to determine the adaptive capabilities of thyrocytes. It was found that with an increase in the concentration of endogenous toxic compounds in the blood of animals, damage is characterized by small-droplet vacuolar degeneration, as well as tissue dystrophy, followed by the formation of zones of moderate proliferation and isolation of follicles into separate thyreones due to connective tissue. This fact indicates morphological restructuring of the parenchyma with possible zones of nodulation, which can serve as a morphological substrate for thyropathies.

Author Biographies

S. Kalashnikova , Volgograd Medical State University of the Ministry of Health care of Russia

doctor of medicine, the chef of anatomy department

L. Polyakova , Volgograd Medical State University of the Ministry of Health care of Russia

associated professor of anatomy department

E. Kalashnikova, Volgograd Medical State University of the Ministry of Health care of Russia

student

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Published

2021-03-22

Issue

Vol. 3 No. 12(64) (2020)

Section

Статьи

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