STUDY OF THE EFFECT OF THE MINERAL COMPLEX "MACROMOL" ON THE DENTAL STATUS AND THE STATE OF THE ORAL CAVITY ORGANS IN RATS
Keywords:
intrauterine hypoxia, dental-jaw system, mineral complex,Abstract
The aim of the study was to study the effect of the "Macromol" mineral complex on the dental status and the state of the oral cavity organs in rats.
Materials and methods. The experiment was carried out on 38 white rats of both sexes: 32 females and 6 males. To reproduce offspring in 3 groups of female rats, 2 males (6 individuals) were added. Then, in these females, presumably from 10 to 19 days of pregnancy, hypoxia of uncoupling of oxidation and phosphorylation processes was reproduced by intraperitoneal administration during pregnancy of warfarin at a dose of 1.5 mg / kg of body weight of rats. After birth, rat pups at 1 month of age. aged were put on a cariogenic diet (7 rats). The intact group consisted of 7 rats. During 30 days, rats, against the background of hypoxia and KgR, received a reos solution of the mineral complex "Macromol" (7 rats).
Results of the study. Mineral complex "Macromol" under conditions of reproduction of intrauterine hypoxia and cariogenic diet showed caries-prophylactic effect in the offspring of these rats. Under its influence, both the number of teeth and the depth of dental caries lesions significantly decreased. The complex showed an antiinflammatory effect in the oral mucosa, reduced lipid peroxidation processes in the liver and, locally, in the bone tissue of the periodontium of rats.
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