THE EFFECT OF MELAXEN ON THE FUNCTIONAL STATE OF THE KIDNEYS, LIPID PEROXIDATION AND METAL ACCUMULATION IN RATS UNDER CONDITIONS OF COMBINED USE OF CADMIUM, LEAD AND ZINC SALTS

Abstract

The research presents the effect of melatonin at a dose of 10 mg / kg on the renal water-electrolyte excretory function, on the degree of heavy metals’ accumulation in the tubular bones of rats, and the activity of lipid peroxidation and antioxidant cell defense in isolated and combined use of zinc chloride at a dose of 1 and 20 mg/kg, lead acetate at a dose of 20 mg/kg, and cadmium sulfate at a dose of 0.5 mg/kg. It was found that in the intragastric administration of heavy metals, the level of diuresis against the background of melaxen introduction was lower than in the isolated use of metals. The renal electrolyte-excretory function of rats using melatonin in conditions of cadmium, lead and zinc intoxication was characterized by a decrease in the excretion of potassium, sodium and calcium compared to the indicators of the animals with the only metal salts introduction. Proteinuria was observed in all experimental groups, with the exception of the group with combined introduction of zinc chloride at a dose of 1 mg / kg and melatonin. Application of melatonin under conditions of intoxication produced by heavy metals helped to reduce the severity of LPO reactions; decalcification of bones and a decrease in the accumulation of metals in the animals’ bone tissue were noted.