PREDICTIVE MARKERS OF THE EFFECTIVENESS OF TREATMENT FOR ALCOHOLIC LIVER DISEASE
Keywords:
alcohol liver disease, predictive markers, chronic hepatitis, liver cirrhosisAbstract
Alcohol consumption is undoubtedly an urgent problem of our time, since it is considered an important risk factor for the development of many diseases, often leading to disability and even death. In the latest comparative assessment of risk factors for the development of various diseases, carried out by the World Health Organization (WHO), alcohol is given an honorable third place. It is second only to risk factors such as promiscuous intercourse and underweight in children and is ahead of factors such as unsafe drinking water, lack of basic sanitation and hygiene, hypertension, high cholesterol, or smoking. ALD is understood as steatosis, alcoholic steatohepatitis, progressive fibrosis, cirrhosis, and hepatocellular carcinoma. It is known that all these diseases develop when alcohol is taken in doses exceeding "safe" ones. It is important to identify ALD at the early stages of its development and prescribe adequate therapy, as a result of which the control over the disease is increased, the number of its complications decreases, the costs of treatment are reduced, and the duration and quality of life of patients with ALD increases. In this connection, the authors have studied possible prognostic markers for the development of alcoholic liver disease in the article.
References
Klinicheskie rekomendacii Rossijskogo obshhestva po izucheniju pecheni po vedeniju vzroslyh pacientov s alkogol'noj bolezn'ju pecheni / V.T. Ivashkin [i dr.] // Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii. - 2017. - №27(6). - S. 20-40. [Clinical Guidelines of the Russian Society for the Study of the Liver for the Management of Adult Patients with Alcoholic Liver Disease/ V.T. Ivashkin [et al.] // Russian journal of gastroenterology, hepatology, coloproctology.-2017.-№27(6).-20-40 https://www.gastro-j.ru/jour/article/view/190
EASL Clinical Practical Guidelines: Management of Alcoholic Liver Diseaase. / P. Mathurin [et al.] // J Hepatol. - 2012. - 57: - P. 399–420. https://doi.org/10.1016/j.jhep.2018.03.018
O’Shea, R.S. Alcoholic Liver Disease. / R.S. O’Shea, S. Dasarathy, A.J. McCullough // Am J Gastroenterol. – 2010. – 105. – P. 14–32. https://pubmed.ncbi.nlm.nih.gov/20034030/
Vaiphei, K. Chronic alcohol intake: indicator towards alcoholic liver disease / K. Vaiphei, K. Gupta, V. Lal // Indian J. Gastroenterol. – 2007. – Vol. 26, №4.–P.180-184. https://pubmed.ncbi.nlm.nih.gov/17986748/
Synergistic association between alcohol intake and body mass index with se-rum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study / R. Loomba [et al.] // Aliment Pharmacol Ther. – 2009. - 30. – R. 1137- 1149. https://pubmed.ncbi.nlm.nih.gov/19737152/
Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk /S. Ballestri [et al.] // Adv. Ther. – 2017. – 34. –P. 1291–1326. https://pubmed.ncbi.nlm.nih.gov/28526997/
Cromie S.L. Chronic hepatitis C: Effect of alcohol on hepatic activity and viral titre / S.L. Cromie // Journal of Hepatology. – 1996. 25 (6). – R. 821–826. https://www.journal-of-hepatology.eu/article/S0168-8278(96)80284-4/fulltext
Excess weight risk factor for alcoholic liver disease / S. Naveau [et al.] // Hepatology. – 1997. – 25. – P. 108–111. https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.510250120
Meier, P. Age, alcohol metabolism and liver disease. / P. Meier, H.K. Seit// Curr. Opin. Clin. Nutr. Metab. Care. – 2008. – 11. – P. 21–26.
Ethnic differences in presentation and severity of alcoholic liver disease / R.E. Levy [et al.] //Alcohol. Clin. Exp. Res. - 2015. - 39. – R. 566–574. https://ucdavis.pure.elsevier.com/en/publications/ethni c-differences-in-presentation-and-severity-ofalcoholic-live/fingerprints/
Verhulst, B. The heritability of alcohol use disorders: A meta-analysis of twin and adoption studies / B. Verhulst, M.C. Neale, K.S. Kendler // Psychol. Med. –2015.– 45. –P. 1061–1072. https://pubmed.ncbi.nlm.nih.gov/25171596/
Variant in PNPLA3 is associated with alcoholic liver disease / C. Tian [et al.] // Nat Genet. – 2010. – 42. – R.21-23. https://www.nature.com/articles/ng.488
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
CC BY-ND
A work licensed in this way allows the following:
1. The freedom to use and perform the work: The licensee must be allowed to make any use, private or public, of the work.
2. The freedom to study the work and apply the information: The licensee must be allowed to examine the work and to use the knowledge gained from the work in any way. The license may not, for example, restrict "reverse engineering."
2. The freedom to redistribute copies: Copies may be sold, swapped or given away for free, in the same form as the original.
