SYNTHESIS AND FUNCTIONALIZATION OF SOME PARA-R-PHENYLIMIDAZO[2,1-B][1,3,4]- THIADIAZOLE DERIVATIVES

Authors

  • R. Rakhmonov , Institute of Chemistry named after V.I. Nikitina National Academy of Sciences of Tajikistan
  • Sh. Sharipov Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan
  • M. Odilzoda Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan
  • B. Safarov Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan
  • A. Kobilzoda Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan
  • A. Abdurakhmonov Tajik State Pedagogical University named after S. Aini

DOI:

https://doi.org/10.31618/ESSA.2782-1994.2021.1.68.15

Keywords:

2-methyl-6-p-iodophenylimidazo[2,1-b][1,3,4]-thiadiazole, 2-(1-chloro-ethyl)-6-pbromophenylimidazo[2,1-b][1,3,4]-thiadiazole, electrophilic substitution, absorption band, stretching vibrations.

Abstract

The article describes the synthesis of new modifications of derivatives of 6-phenyl-, 6-piodophenyl- and 6-p-bromophenylimidazo[2,1-b][1,3,4]-thiadiazoles - N -((6-(4-iodophenyl)-2-R-imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methyl)-alkyl/ heterylamine based on the Mannich reaction, bromination 2((ethylsulfonyl)methyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole and the structure of the resulting compounds was established on the basis of IR spectroscopy. It was shown that the presence of substituents at the 2-nd position of the thiadiazole fragment and substituents at the 5th and 6th positions of the imidazole fragment of this heterocycle cause the appearance of a nonequivalent absorption band in the imidazo-thiadiazole fragment.

Author Biographies

R. Rakhmonov, , Institute of Chemistry named after V.I. Nikitina National Academy of Sciences of Tajikistan

leading researcher, candidate of chemical sciences,  head. Laboratory of Chemistry of Heterocyclic Compounds

Sh. Sharipov , Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan

Post-graduate student at the Laboratory of Chemistry of Heterocyclic Compounds

M. Odilzoda , Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan

Researcher, Laboratory of Chemistry of Heterocyclic Compounds

B. Safarov , Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan

Post-graduate student at the Laboratory of Chemistry of Heterocyclic Compounds

A. Kobilzoda, Institute of Chemistry. IN AND. Nikitina National Academy of Sciences of Tajikistan

Master in the Laboratory of Chemistry of Heterocyclic Compounds

A. Abdurakhmonov, Tajik State Pedagogical University named after S. Aini

4th year student of the Department of Organic and Biological Chemistry

References

Arya, V. P.; Fernandes, F.; Sudarsanam, V. /Synthesis of nitroheterocycles. I. Synthesis of 2substituted 5-nitrothiophene derivatives and their antimicrobial activity. //CIBA Res. Cent.,Bombay, India. Indian Journal of Chemistry (1972), 10(6), 598601.

Andanappa K. Gadad, Malleshappa N. Noolvi and Rajshekhar V. Karpoormath. / Synthesis and antitubercular activity of a series of 2- sulfonamido/trifluoromethyl-6-substituted imidazo[2,1-b][1,3,4]thiadiazole derivatives.// Bioorg. Med. Chem. 2004. 12. 5651–5659.

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Published

2021-05-14

Issue

Vol. 1 No. 4(68) (2021)

Section

Статьи

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