GENDER DIFFERENCES IN MYOCARDIAL REVASCULARIZATION IN INDIVIDUALS WITH ACUTE CORONARY SYNDROME AFTER CORONARY ARTERY BYPASS SURGERY

Authors

  • F. Ibrahimov Azerbaijan Medical University

DOI:

https://doi.org/10.31618/ESSA.2782-1994.2021.1.70.66

Keywords:

Gender differences, coronary artery bypass, coronary artery disease, acute coronary syndrome, female sex, male sex, diabetes mellitus, ejection fraction, cardiac death, myocardial infarction.

Abstract

The purpose of this study was to study the gender differences in the frequency of major cardiovascular and cerebrovascular events (MACCE), cardiac mortality, mortality from all other causes, and to study the relationship between these conditions and risk factors in patients after CABS. Materials and methods. The study included 717 patients after the CABS, of whom 596 were male and 121 female. Patients admitted to hospital with acute coronary syndrome (ACS) and only those undergoing CABS surgery participated in the study. All clinical data on demographic characteristics, risk factors, and complications were selected and the survival and mortality analysis was performed retrospectively. The results. In assessing the age indicator, it was found that females (59.9±7.3 years) were significantly older than males (56.3±8.2 years) (p=0.00012). In the estimation of the 30-day mortality rate, it was shown that this indicator was 3.4% for women and 0.5% for men, the differences were statistically significant (p=0.004). Identical differences were also observed for 1-year mortality, as this indicator was 3.5% for women, while for men it was 0.7% and significantly lower (p=0.012). The 5-year MACCE percentage was 19% for women and 16.9% for men, i.e. the difference was not statistically significant (p=0.585). Conclusion. The main finding of this study was the difference between the profiles of female and male populations of preoperative patients after CABS. As in other studies in this area, and in this study, female patients were older, more likely to have AH, DM, obesity and anaemia than male patients.

Author Biography

F. Ibrahimov , Azerbaijan Medical University

Azerbaijan Medical University

References

Johnston A., Mesana T.G., Lee D.S. et al. Sex Differences in Long‐Term Survival After Major Cardiac Surgery: A Population‐Based Cohort Study J Am Heart Assoc 2019;8(17):e013260. https://doi.org/10.1093/ejcts/ezr039. 10.1161/JAHA.119.013260.

Nashef S.A., Roques F., Sharples L.D. et al. EuroSCORE II. Eur J Cardiothorac Surg 2012;41(4):734–45. https://doi.org/10.1093/ejcts/ezr039. 10.1093/ejcts/ezs043.

Ahmed W.A., Tully P.J., Knight J.L., Baker R.A. Female sex as an independent predictor of morbidity and survival after isolated coronary artery bypass grafting. Ann Thorac Surg 2011;92(1):59-67. doi:10.1016/j.athoracsur.2011.02.033.

Swaminathan R.V., Feldman D.N., Pashun R.A. et al. Gender differences in in-hospital outcomes after coronary artery bypass grafting. Am J Cardiol

;118(3):362–8. https://doi.org/10.1093/ejcts/ezr039. 10.1016/j.amjcard.2016.05.004.

Norheim A., Segadal L. Relative survival after CABG surgery is poorer in women and in patients younger than 70 years at surgery. Scand Cardiovasc J

:45(4);247-51. https://doi.org/10.1093/ejcts/ezr039. 10.3109/14017431.2011.582139.

Saxena A., Dinh D., Smith J.A. et al. Sex differences in outcomes following isolated coronary artery bypass graft surgery in Australian patients: analysis of the Australasian Society of Cardiac and Thoracic Surgeons cardiac surgery database. Eur J

Cardiothorac Surg 2012;41(4):755-62. https://doi.org/10.1093/ejcts/ezr039.

Sun L., Tu J., Bader Eddeen A., Liu P. Prevalence and long‐term survival after coronary artery bypass grafting in men and women with heart failure and preserved versus reduced ejection fraction. J Am Heart Assoc 2018;7:e008902. https://doi.org/10.1161/JAHA.118.008902.

O'Connor N.J., Morton J.R., Birkmeyer J.D. et al. Effect of Coronary Artery Diameter in Patients Undergoing Coronary Bypass Surgery. Northern New

England Cardiovascular Disease Study Group. Circulation 1996;93(4):652–5. https://doi.org/10.1161/01.cir.93.4.652.

Ibrahim M.F., Paparella D., Ivanov J. et al. Gender-related differences in morbidity and mortality during combined valve and coronary surgery. J Thorac Cardiovasc Surg 2003;126(4):959–64. https://doi.org/10.1016/s0022-5223(03)00355-6.

Vaccarino V., Lin Z.Q., Kasl S.V. et al. Gender differences in recovery after coronary artery bypass surgery. J Am Coll Cardiol 2003;41(2):307–14. https://doi.org/10.1016/s0735-1097(02)02698-0.

Koch C.G., Khandwala F., Nussmeier N., Blackstone E.H. Gender and outcomes after coronary artery bypass grafting: a propensity-matched comparison. J Thorac Cardiovasc Surg 2003;126(6):2032-43. https://doi.org/10.1016/s0022-5223(03)00950-4.

Howell N.J., Keogh B.E., Bonser R.S. et al. Mild renal dysfunction predicts in-hospital mortality and post-discharge survival following cardiac surgery. Eur J Cardiothorac Surg 2008;34(2):390–5. https://doi.org/10.1016/j.ejcts.2008.04.017.

Puskas J.D., Kilgo P.D., Kutner M. et al. Оffpump techniques disproportionately benefit women and narrow the gender disparity in outcomes after coronary artery bypass surgery. Circulation 2007;116(11 Suppl):I192–9. https://doi.org/10.1161/CIRCULATIONAHA.106.678979.

van Straten A.H., Soliman Hamad M.A., van Zundert A.A. et al. Diabetes and survival after coronary artery bypass grafting: Comparison with an age and sex matched population. Eur J Cardiothorac Surg 2010;37(5):1068–74. doi: 10.1016/j.ejcts.2009.11.042.

denRuijter H.M., Haitjema S., van der Meer M.G. IMAGINE Investigators. Long-term outcome in men and women after CABG; results from the IMAGINE trial. Atherosclerosis 2015;241(1):284-8. https://doi.org/10.1016/j.atherosclerosis.2015.02.039.

Howell N.J., Keogh B.E., Bonser R.S. et al. Mild renal dysfunction predicts in-hospital mortality and post-discharge survival following cardiac surgery. Eur J Cardiothorac Surg 2008;34(2):390–5. doi.org/10.1016/j.ejcts.2008.04.017.

Ter Woorst J.F., van Straten A.H.M., Houterman S., Soliman-Hamad M.A. Sex Difference in Coronary Artery Bypass Grafting: Preoperative Profile and Early Outcome. J Cardiothorac Vasc Anesth 2019;33(10):2679-84. doi: 10.1053/j.jvca.2019.02.040. 18. Blasberg J.D., Schwartz G.S., Balaram S.K. The role of gender in coronary surgery. Eur J Cardiothorac Surg 2011;40(3):715–21. https://doi.org/10.1016/j.ejcts.2011.01.003.

Velazquez E.J., Williams J.B., Yow E. et al. Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy. Ann Thorac Surg 2012;93(2):523–30. https://doi.org/10.1016/j.athoracsur.2011.10.064.

Wrobel K., Stevens S.R., Jones R.H. et al. Influence of baseline characteristics, operative conduct, and postoperative course on 30-day outcomes of coronary artery bypass grafting among patients with left ventricular dysfunction: results from the surgical treatment for ischemic heart failure (STICH) trial. Circulation 2015;132(8):720–30. https://doi.org/10.1161/CIRCULATIONAHA.114.014932.

Hillis G.S., Zehr K.J., Williams A.W. et al. Outcome of patients with low ejection fraction undergoing coronary artery bypass grafting: renal function and mortality after 3.8 years. Circulation 2006;114(1 Suppl):I414–9. https://doi.org/10.1161/CIRCULATIONAHA.105.000661.

Hsich E.M., Pina I.L. Heart failure in women: a need for prospective data. J Am Coll Cardiol 2009;54(6):491–8. DOI: 10.1016/j.jacc.2009.02.066.

Jarvie J.L, Foody J.M. Recognizing and improving health care disparities in the prevention of cardiovascular disease inwomen. Curr Cardiol Rep 2010;12(6):488–96. https://doi.org/10.1007/s11886-010-0135-4.

van Straten A.H., Soliman Hamad M.A., van Zundert A.A. et al. Preoperative renal function as a predictor of survival after coronary artery bypass grafting: Comparison with a matched general population. J Thorac Cardiovasc Surg

;138(4):971–6. DOI: https://doi.org/10.1016/j.jtcvs.2009.05.026.

Downloads

Published

2021-07-10

Issue

Section

Статьи