INFLUENCE OF DOSED PHYSICAL LOADS ON EMOTIONAL AND MOTIVATIONAL STATE, ELECTRICAL ACTIVITY OF THE BRAIN, BDNF AND CORTISOL LEVELS IN RATS WITH ALCOHOL DEPENDENCE

Authors

  • Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, NAMSU
  • Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, NAMSU
  • Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, NAMSU
  • Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, NAMSU
  • Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, NAMSU

Keywords:

model of alcohol dependence, anxiety, depression, electrical activity of the brain, BDNF, cortisol

Abstract

In an experimental study conducted on rats, the effect of dosed physical loads (running in a wheel) on the suppression of anxiety and depression caused by chronic alcohol consumption was established. An increase in the spectral power of alpha-range biopotentials in the brain structures responsible for emotional-motivational behavior has been shown. A decrease in the level of cortisol and an increase in the synthesis of BDNF in the hippocampus, and activation of the hormonal and neurotrophic links of the peripheral system of adaptation were revealed.

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Published

2021-03-22

Issue

Vol. 5 No. 11(63) (2020)

Section

Статьи

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