ENDOSCOPIC TREATMENT OF ESOPHAGEAL-BRONCHIAL FISTULA IN A PATIENT WITH A LEYDEN MUTATION

Authors

  • A. Gasanov Sklifosovsky Research Institute for Emergency Medicine
  • S. Danielyan Sklifosovsky Research Institute for Emergency Medicine
  • E. Tarabrin Sklifosovsky Research Institute for Emergency Medicine
  • A. Kanibolotskiy Sklifosovsky Research Institute for Emergency Medicine
  • E. Nikolaeva Sklifosovsky Research Institute for Emergency Medicine
  • O. Kvardakova Sklifosovsky Research Institute for Emergency Medicine
  • R. Muslimov Sklifosovsky Research Institute for Emergency Medicine
  • K. Kammaev Sklifosovsky Research Institute for Emergency Medicine
  • V. Palagina Sklifosovsky Research Institute for Emergency Medicine

DOI:

https://doi.org/10.31618/ESSA.2782-1994.2021.1.69.41

Keywords:

endoscopy, bronchoscopy, esophagoscopy, Factor V Leiden, Bronchoesophageal fistula, fistula, bronchus, esophagus.

Abstract

Bronchoesophageal Fistula (BEF) is an uncommon condition related to complex thoracic surgery. The development of BEF is usually an indication of the progression of bronchial or lung cancer; whereas the etiology of this illness being recorded as benign is much rarer – not exceeding 4 - 6%. [1, 2].

Surgery is the main method for treating patients who have benign BEF, allowing for the reliable result. At the same time, similar operations are extremely traumatic and are fraught with the development of post-operation complications, especially when concerning patients with genetically determined coagulopathy. 

Factor V Leiden mutation is a hereditary coagulopathy in which there is a point mutation in the gene that encodes blood coagulation factor V. Factor V Leiden mutation is the most common cause of the hereditary disposition to thrombosis, heart attacks, strokes in Europeans. The frequency of occurence among the population of the USA is 4 – 6% [3]. 

We present our own observation of successful endoscopic surgery to treat BEF in a patient with Factor V Leiden mutation and chronic pulmonary embolism. 

References

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Price DT, Ridker PM. Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective. Ann Intern Med 1997;127(10):895-903. https://doi.org/10.7326/0003-4819-127-10-199711150-00007

Albucher JF, Guiraud-Chaumeil B, Choller F et al. Frequency of resistance to activated protein С due to factor V mutation in young patients with ischemic stroke. Stroke 1996;27(4):766-767.

Ahn JY, Jung HY, Choi JY et al. Benign bronchoesophageal fistula in adults: endoscopic closure as primary treatment. Gut Liver 2010;4(4):508513. https://doi.org/10.5009/gnl.2010.4.4.508

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Published

2021-06-15

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